Rupies are used in a variety of places, including but not limited to:
- Performing rupie draws
- Uncapping characters, weapons, and summons
- Reducing weapons and summons
- Upgrading Sierokarte's Shop for crafting Revenant Weapons
It is generally agreed that the best way to accumulate a lot of rupies is by joining coop rooms. Because it does not require any AP, players earn many treasures quickly that can be sold for rupies.